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US 2022/0187236 A1Published application
Enhanced chloride selective membrane
AssigneeSiemens Healthcare Diagnostics Inc.
InventorsBo Peng, David Thompson
Life of this patent
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Abstract
There is provided a chloride selective membrane including an epoxide-based matrix reacted with a stoichiometric amount of an amino compound and an activator such that the epoxide-based matrix comprises a number of quaternary ammonium groups.
Claims19
A chloride selective electrode for detecting chloride in multiple biological samples, the chloride selective electrode comprising:
- an inert substrate;
- a chloride sensitive membrane formed on the inert substrate, wherein the chloride sensitive membrane is provided with a plurality of quaternary functional groups, and wherein the chloride sensitive membrane comprises:
- an epoxide-based matrix dispensed on the inert substrate, wherein the epoxide-based matrix comprises an epoxy resin having a predetermined number of epoxide groups per molecule;
- a mixture of an amino compound and an activator dispensed onto a surface of the epoxide-based matrix, wherein the amino compound and activator are present in the mixture in a stoichiometric amount relative to the number of epoxide groups in the epoxide-based matrix, and wherein the stoichiometric amount is in a range of from about 0.5:1 to about 1.5:1, and wherein the mixture comprises reactive species;
- and
- wherein the chloride sensitive membrane is stable for at least 14 days upon exposure to at least one biological sample.
3 more elements
A chloride selective sensor for detecting chloride in multiple biological samples, the chloride selective sensor comprising:
- a housing;
- a fluid channel member;
- a sensor plate comprising an inert substrate;
- a chloride sensitive membrane formed on the inert substrate of the sensor plate,
- wherein the chloride sensitive membrane is provided with a plurality of quaternary functional groups, wherein the chloride sensitive membrane comprises:
- an epoxide-based matrix dispensed on the inert substrate, wherein the epoxide-based matrix comprises an epoxy resin having a predetermined number of epoxide groups per molecule;
- a mixture of an amino compound and an activator dispensed onto a surface of the epoxide-based matrix, wherein the amino compound and activator are present in the mixture in a stoichiometric amount relative to the number of epoxide groups in the epoxide-based matrix, and wherein the stoichiometric amount is in a range of from about 0.5:1 to about 1.5:1, and wherein the mixture comprises reactive species;
- at least one fluid connector that allows for introduction of the biological sample into the sensor and travel of the biological sample to the fluid channel member;
- and
- wherein the chloride selective sensor is arranged such that the biological sample introduced to the sensor through the at least one fluid connector travels to the fluid channel member and over the chloride sensitive membrane disposed on the sensor plate;
- and
- wherein the chloride sensitive membrane is stable for at least 14 days upon exposure to at least one biological sample.
9 more elements
Dependencies are inferred from the claim text.