White Blood Cell Population Dynamics
AssigneeThe General Hospital Corporation
InventorsJohn M. Higgins, Anwesha Chaudhury
Life of this patent
Estimating the term…
Abstract
Systems and methods for modeling and detecting white blood cell population dynamic for diagnosis and treatment, e.g., of acute coronary syndrome or leukocytosis.
Claims20
A system comprising a processing device, and one or more computer-readable non-transitory media storing instructions that are executable by the processing device, and upon execution cause the processing device to perform operations comprising:
- estimating a value of a parameter indicative of white blood cell (WBC) population dynamics of a patient based on data indicative of a property value of each WBC in a sample of white blood cells (WBCs) of the patient, the property value of a WBC being indicative of an age of the WBC;
- and
- providing information for treatment or diagnosis of a condition of the patient associated with an inflammatory or immune system response based on the parameter.
The system of claim 35, wherein the data is indicative of cell size, internal complexity, nuclear lobularity, peroxidase content, or DNA/RNA content of each WBC in the sample.
The system of claim 37, further comprising comparing the one or more values to a reference value.
The system of claim 38, wherein the reference value represents an identified cohort of subjects, or a value determined at an earlier or later point in time in the same subject.
A method comprising:
- estimating a value of a parameter indicative of white blood cell (WBC) population dynamics of a patient based on data indicative of a property value of each WBC in a sample of white blood cells (WBCs) of the patient, the property value of a WBC being indicative of an age of the WBC;
- and
- providing information for treatment or diagnosis of a condition of the patient associated with an inflammatory or immune system response based on the parameter.
Dependencies are inferred from the claim text.