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US 2022/0186294 A1Published application
Nanogap Device for Biopolymer Identification
AssigneeUniversal Sequencing Technology Corporation
InventorsPeiming Zhang, Ming Lei, Kisup Chung
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Abstract
This invention provides a device for sequencing and identification of biopolymers electronically.
Claims62
A system for identification, characterization, and/or sequencing of a biopolymer comprising,
- a. a substrate;
- b. a nanogap formed by a first electrode and a second electrode placed next to each other on the substrate;
- c. a nanostructure configured to have a dimension about or comparable to the size of the nanogap and configured to bridge the nanogap by attaching one end to the first electrode and another end to the second electrode through a chemical bond;
- d. a sensing molecule attached to the nanostructure configured to interact with the biopolymer and perform a biochemical reaction;
- e. a gate electrode placed between the nanogap and the substrate;
- and
- f. a first insulation layer separating the gate electrode and the nanogap together with the first and the second electrodes.
4 more elements
A method for identification, characterization, and/or sequencing of a biopolymer comprising,
- a. providing a substrate;
- b. building a second insulation layer on the substrate, wherein the second insulation layer is optional when the substrate is non-conductive or coated with a non-conductive material;
- c. building a gate electrode layer on the second insulation layer, or directly on the substrate when the second insulation layer is absent;
- d. building a first insulation layer on top of the gate electrode layer;
- e. building a first electrode and a second electrode on the first insulation layer, and placing them substantially next to each other to form a nanogap;
- f. providing a nanostructure comprising a dimension substantially comparable to the nanogap and is configured to bridge the nanogap by attaching one end to the first electrode and another end to the second electrode through a chemical bond;
- and
- g. providing a sensing molecule configured to interact with the biopolymer and perform a biochemical reaction, and attaching the sensing molecule to the nanostructure at a predefined location.
5 more elements
Dependencies are inferred from the claim text.