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US 2022/0186278 A1Published application
Analyte sensors for sensing ketones and methods of using the same
AssigneeAbbott Diabetes Care Inc.
InventorsZenghe Liu, Stephen Oja, Tianmei Ouyang, Benjamin J. Feldman
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Abstract
The present disclosure provides an analyte sensor for use in detecting ketones. In certain embodiments, a ketones-responsive active site of a presently disclosed analyte sensor includes an enzyme system comprising β-hydroxybutyrate dehydrogenase and NADH oxidase disposed on a surface of a platinum working electrode. The present disclosure further provides methods for detecting ketones using the disclosed analyte sensors.
Claims20
An analyte sensor comprising:
- (i) a sensor tail comprising at least a first working electrode;
- (ii) a ketones-responsive active area disposed upon a surface of the first working electrode, wherein the ketones-responsive active area comprises an enzyme system comprising a 3-hydroxybutyrate dehydrogenase and a NADH oxidase;
- and
- (iii) a mass transport limiting membrane permeable to ketones that overcoats at least a portion of the ketones-responsive active area.
1 more element
A method for detecting ketones comprising:
- (i) providing an analyte sensor comprising:
- (a) a sensor tail comprising at least a first working electrode;
- (b) a ketones-responsive active area disposed upon a surface of the first working electrode, wherein the ketones-responsive active area comprises an enzyme system comprising β-hydroxybutyrate dehydrogenase and NADH oxidase;
- and
- (c) a mass transport limiting membrane permeable to ketones that overcoats at least a portion of the ketones-responsive active area;
- (ii) applying a potential to the first working electrode;
- (iii) obtaining a first signal at or above an oxidation-reduction potential of the ketones-responsive active area, the first signal being proportional to a concentration of ketones in a fluid contacting the ketones-responsive active area;
- and
- (iv) correlating the first signal to the concentration of ketones in the fluid.
6 more elements
Dependencies are inferred from the claim text.