Compositions and methods for treating cushing's disease
AssigneeThe Regents of the University of California
InventorsAnthony Heaney, Dongyun Zhang, Robert Damoiseaux
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Abstract
Disclosed herein are methods of treating a disease or disorder characterized by an increased secretion of adrenocorticotropic hormone (e.g., Cushing's disease). Also disclosed herein are methods of identifying compounds for use in treating said diseases or disorders.
Claims24
A method of treating a disease or disorder characterized by an increased secretion of adrenocorticotropic hormone, comprising administering to a subject in need thereof a compound that inhibits both the secretion of adrenocorticotropic hormone and tumor growth.
A method of treating Cushing's disease, comprising administering to a subject in need thereof a compound that inhibits both the secretion of adrenocorticotropic hormone and tumor growth.
15-19. (canceled)
21-23. (canceled)
26-30. (canceled)
A method of identifying a compound that inhibits the secretion of adrenocorticotropic hormone (ACTH) and tumor growth, comprising the steps of:
- a) contacting a plurality of AtT20 cells with the compound, thereby forming an assay mixture;
- b) quantifying the ability of the compound to inhibit the secretion of ACTH;
- and
- c) quantifying the ability of the compound to inhibit nuclei;
- wherein the compound is identified as being an inhibitor of ACTH secretion and tumor growth if the compound inhibits both ACTH secretion and nuclei growth at a predetermined threshold.
34-65. (canceled)
Dependencies are inferred from the claim text.