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AssigneeEvogen, Inc.
InventorsTodd WALLACH, Elisa A. WAXMAN, John GLEDHILL, Richard ST. CLAIR, Elizabeth BRAND
Estimating the term…
Epileptic seizures are difficult to diagnose and are often difficult to distinguish from several conditions with similar presentations, and therefore, diagnosis of seizures is often a long, expensive, and unreliable process. This invention provides biomarkers for identifying seizures and epilepsy, assays for measuring and assessing biomarker concentration, predictive models based on biomarkers and computational systems for detecting, assessing and diagnosing phasic and tonic changes associated with seizures and epilepsy in all clinical and healthcare settings. Diagnostic and treatment methods, systems, kits, and predictive models provided herein, provide quantitative and/or qualitative assessment in order to allow patients to proceed immediately to diagnostic and/or treatment protocols, and assess therapeutic treatment effectiveness.
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A method of treating epilepsy in a patient in need of epilepsy treatment, the method comprising:
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A method of treating epilepsy in a patient having an altered blood level of one or more biomarkers selected from Table 2, the method comprising administering to the patient one or more therapeutic agents selected from the group consisting of phenytoin, fosphenytoin, midazolam, pregabalin, acetazolamide, methsuximide, ethotoin, piracetam, nitrazepam, paraldehyde, stiripentol, vigabatrin, brivaracetam, perampanel, rufinamide, lurasidone HCl, carbamazepine, clobazam, clonazepam, diazepam, divalproex, eslicarbazepine acetate, ethosuxemide, ezogabine, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, lorazepam, oxcarbazepine, phenobarbital, primidone, tiagabine, topiramate, valproic acid, zonisamide, cannabis-based drugs, and pharmaceutically acceptable salts, prodrugs, and derivatives thereof.
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A non-transitory computer readable storage medium for determining a likelihood that a human subject afflicted with one or more seizures will be responsive to a treatment regimen that comprises administering to the subject an epilepsy therapeutic agent, the non-transitory computer readable storage medium storing one or more programs for execution by one or more processors of a computer system, the one or more computer programs comprising instructions for:
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Dependencies are inferred from the claim text.