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US 2022/0178947 A1Published application
Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell
AssigneeCyrano Therapeutics, Inc.
InventorRobert I. HENKIN
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Abstract
Disclosed herein are methods for diagnosing a subject with loss and/or distortion of taste or smell, e.g., hyposmia, dysosmia, anosmia, phantosmia, hypogeusia, dysgeusia, phantogeusia, and/or ageusia. Also disclosed herein are methods and compositions for treating a subject for loss and/or distortion of taste or smell, e.g., hyposmia, dysosmia, anosmia, phantosmia, hypogeusia, dysgeusia, phantogeusia, and/or ageusia.
Claims15
1-64. (canceled)
A method comprising:
- (a) measuring a level of sonic hedgehog (SHH) and a level of cyclic nucleotide in a biological sample that comprises nasal mucus, saliva, or a combination thereof;
- (b) with aid of a computer system comprising a computer processing unit and computer readable medium, identifying a decreased level of SHH and a decreased level of the cyclic nucleotide, wherein the identifying comprises:
- i. comparing the level of SHH and the level of the cyclic nucleotide in the biological sample to a SHH reference level and a cyclic nucleotide reference level respectively, stored at least transiently on the computer readable medium;
- ii. detecting a lower level of SHH and a lower level of the cyclic nucleotide in the biological sample, relative to the SHH reference level and the cyclic nucleotide reference level respectively;
- and
- iii. communicating a presence of the lower levels based on the detecting of (ii).
3 more elements
Dependencies are inferred from the claim text.