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AssigneeSera Prognostics, Inc.
InventorsDurlin Edward Hickok, John Jay Boniface, Gregory Charles Critchfield, Tracey Cristine Fleischer
Estimating the term…
The disclosure provides biomarker panels, methods and kits for determining the probability for preterm birth in a pregnant female. The present disclosure is based, in part, on the discovery that certain proteins and peptides in biological samples obtained from a pregnant female are differentially expressed in pregnant females that have an increased risk of developing in the future or presently suffering from preterm birth relative to matched controls. The present disclosure is further based, in part, on the unexpected discovery that panels combining one or more of these proteins and peptides can be utilized in methods of determining the probability for preterm birth in a pregnant female with relatively high sensitivity and specificity. These proteins and peptides disclosed herein serve as biomarkers for classifying test samples, predicting a probability of preterm birth, monitoring of progress of preterm birth in a pregnant female, either individually or in a panel of biomarkers.
A panel of isolated biomarkers comprising N of the biomarkers listed in Tables 1 through 63.
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A method of determining probability for preterm birth in a pregnant female, the method comprising detecting a measurable feature of each of N biomarkers selected from the biomarkers listed in Tables 1 through 63 in a biological sample obtained from said pregnant female, and analyzing said measurable feature to determine the probability for preterm birth in said pregnant female.
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A method of predicting GAB, the method comprising detecting a measurable feature of each of N biomarkers selected from the biomarkers listed in Tables 1 through 63 in a biological sample obtained from a pregnant female, and analyzing said measurable feature to predict GAB.
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A method of detecting and/or quantifying one or more biomarkers selected from biomarkers listed in Tables 1 through 63 in a biological sample from a pregnant female, said method comprising:
Dependencies are inferred from the claim text.