Back to results
US 2022/0178935 A1Published application
Ex vivo protease activity detection for disease detection/diagnostic, staging, monitoring and treatment
AssigneeGlympse Bio, Inc.
InventorsFaycal Touti, Wendy Winckler Adamovich, Sophie Cazanave, Mehar Cheema, Robert S. Langer
Life of this patent
Estimating the term…
Abstract
The present application provides compositions and methods for determining a disease or condition in a subject. The method comprises contacting a body fluid with a molecule comprising a reporter thereof and the reported is cleaved by an agent in the body fluid. Diseases and conditions that can be determined by the method are also described.
Claims20
A method comprising:
- contacting a body fluid sample from a subject with a molecule ex vivo,
- wherein said molecule comprises a reporter, and
- wherein said molecule reacts with an agent from said body fluid, causing said reporter to form a detectable signal,
- detecting a rate of formation or an amount of said detectable signal,
- determining a disease or condition of said subject based on said detection,
- wherein said disease or condition is a certain fibrosis stage or a certain nonalcoholic fatty liver disease activity score (NAS) of Non-alcoholic steatohepatitis (NASH).
3 more elements
Dependencies are inferred from the claim text.