Genetic amplified tumor homing nanoparticles and compositions and methods thereof
AssigneeUniversity of Massachusetts
InventorGang Han
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Abstract
The invention provides novel genetic probes and bioactive agents and compositions and methods of use thereof in diagnostic and therapeutic applications.
Claims22
A genetic probe for specific upregulation of transferrin receptor (TfR) expression level in an infected prostate cancer (PCa) cell without upregulating TfR expression level in a nonmalignant prostate cell, wherein the genetic probe comprises a promoter of differential display code 3 (DD3) gene and TfR gene and upregulation of TfR expression level results in an increase of TfR level on the PCa cell's surface.
A method for increasing transferrin receptor (TfR) level on a prostate cancer (PCa) cell surface, comprising infecting a PCa cell with a genetic probe capable of specific upregulation of TfR expression level in the infected PCa cell without upregulation of TfR expression level in infected nonmalignant prostate cells.
15-23. (canceled)
30-40. (canceled)
Dependencies are inferred from the claim text.