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US 2022/0178917 A1Published application
Biomolecular sensors with desalting module and related methods
AssigneeFemtoDx
InventorPritiraj Mohanty
Life of this patent
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Abstract
Systems and methods for removing ions from a sample (i.e., desalting) are generally described. In some embodiments, “desalting” comprises removing ions from a sample, the sample also comprising an analyte, such as a protein, a hormone, or an antigen. Unwanted ions can increase the noise when detecting or sensing a signal from an analyte within the sample.
Claims38
A system for removing a plurality of ions from a sample, the system comprising:
- a first electrode;
- a first porous material adjacent to at least a portion of the first electrode;
- a second electrode in electrical communication with the first electrode;
- and
- a second porous material adjacent to at least a portion of the second electrode.
2 more elements
A system for removing a plurality of ions from a sample, the system comprising:
- a substrate;
- a desalting chamber proximate the substrate, the desalting chamber comprising:
- a first electrode,
- a first porous material adjacent to at least a portion of the first electrode,
- a second electrode in electrical communication with the first electrode, and
- a second porous material adjacent to at least a portion of the second electrode;
- a microfluidic channel;
- and
- a sensing chamber proximate the substrate, the sensing chamber comprising:
- at least one sensor,
- wherein the desalting chamber and the sensing chamber are in fluidic communication via the microfluidic channel.
8 more elements
A method of removing a plurality of ions from a sample, the method comprising:
- flowing the sample into a desalting chamber, the desalting chamber comprising:
- a first electrode,
- a first porous material adjacent to at least a portion of the first electrode,
- a second electrode in electrical communication with the first electrode, and
- a second porous material adjacent to at least a portion of the second electrode;
- applying a first voltage of a first sign to the first electrode;
- applying a second voltage of a second sign to the second electrode;
- attracting at least a portion of the plurality of ions towards the first electrode and the second electrode;
- flowing the sample into a microfluidic channel;
- flowing the sample into a sensing chamber, wherein the sensing chamber and the desalting chamber are fluidically connected via the microfluidic channel;
- and
- sensing an analyte within the sample.
9 more elements
A system for removing a plurality of ions from a sample, the system comprising:
- a microfluidic channel, the microfluidic channel comprising:
- a fluid inlet and a fluid outlet downstream the fluid inlet, wherein a valve is adjacent the fluid inlet;
- a piston disposed within the fluidic channel and proximate the fluid inlet;
- a force generator adjacent to the piston;
- and
- a porous material within the fluidic channel, wherein the porous material is disposed between the valve the fluid outlet, and
- wherein the piston is configured to move a sample downstream the microfluidic channel.
4 more elements
A system for removing a plurality of ions from a sample, the system comprising:
- a substrate;
- a desalting chamber proximate the substrate, the desalting chamber comprising:
- a microfluidic channel, the microfluidic channel comprising:
- a fluid inlet and a fluid outlet downstream the fluid inlet, wherein
- a valve is adjacent the fluid inlet;
- a piston disposed within the fluidic channel and proximate the fluid inlet;
- a force generator adjacent to the piston;
- and
- a porous material within the fluidic channel, wherein the porous material is disposed between the valve the fluid outlet;
- and
- a sensing chamber proximate the substrate, the sensing chamber comprising:
- at least one sensor,
- wherein the piston is configured to move a sample downstream within the microfluidic channel, and
- wherein the desalting chamber and the sensing chamber are in fluidic communication via the microfluidic channel.
11 more elements
A method of removing a plurality of ion from a sample, the method comprising:
- flowing a sample into a desalting chamber, the desalting chamber comprising:
- a microfluidic channel, the microfluidic channel comprising:
- a fluid inlet and a fluid outlet downstream the fluid inlet, wherein
- a valve is adjacent the fluid inlet;
- a piston disposed within the fluidic channel and proximate the fluid inlet;
- a force generator adjacent to the piston;
- and
- a porous material within the fluidic channel, wherein the porous material is disposed between the valve the fluid outlet;
- providing a signal to the force generator to move the piston;
- flowing the sample through the porous material into the fluid outlet;
- flowing the sample into a sensing chamber, wherein the sensing chamber and the desalting chamber are fluidically connected via the microfluidic channel;
- and
- sensing an analyte within the sample.
10 more elements
Dependencies are inferred from the claim text.