Biorelevant composition

Abstract

A biorelevant precursor composition suitable, upon dispersing, dilution or suspension in an aqueous medium, for simulating fed-state gastric fluids of mammalian species, wherein said biorelevant precursor composition comprises a substantially solid/sol-id-like concentrate, a viscous gel-like concentrate, or a liquid fat dispersion/concentrate, comprising at least one primary component selected from each of the following groups of primary components comprising: i) Triglyceride and/or diglyceride and/or monoglyceride or any combinations thereof in an amount of from 1-70% by weight; ii) Lecithin and/or lysolecithin in an amount of from 1-45% by weight; iii) Carbohydrate in an amount of from 15-70% by weight; and iv) Water or other aqueous medium in an amount of from 1-70% by weight; wherein the weight ratio of total fats (one or more primary components from each of groups i) and ii) combined): total carbohydrates (one or more primary components from group iii) combined) is between 20:1 to 1:20; and the weight ratio of glyceride:lecithin and/or lysolecithin is between 45:1 and 1:45; and in addition at least one additional component selected from at least one of the following: (i) fatty acids (between 0.01-15% by weight); (ii) bile acid/salt (between 0.01-3% by weight); (iii) enzymes (between 0.01-2% by weight); (iv) cholesterol, sterols (between 0.01-5% by weight); (v) buffer agents (between 0.01-4% by weight); (vi) osmotic agents (between 0.01-10% by weight); 52 (vii) proteins (collagen, protein hydrolysates, amino acids) (between 0.01-30% by weight); (viii) mucin (between 0.1-5% by weight); (ix) viscosity modifier (between 0.1-5% by weight); and (x) preservatives, stabilizers (between 0.01-3% by weight), such as a) anti-oxidants, b) chelating agents, c) buffers (inorganic or organic), and d) antimicrobials; all percentages being by dry weight. A method of producing these compositions is also provided.

Dependencies are inferred from the claim text.