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US 2022/0178809 A1Published application
Sample analysis for mass cytometry
AssigneeFluidigm Canada Inc.
InventorAlexander V. Loboda
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Abstract
The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the ICP, followed by analysis by mass cytometry.
Claims29
A laser ablation system comprising:
- a) a laser capable of producing laser illumination;
- b) a laser ablation cell comprising a substrate for holding a sample to be analyzed or a stage configured to receive the substrate;
- and
- c) an injector for carrying an ablation plume to an inductively coupled plasma (ICP), said injector defining an injector opening and an injector lumen,
- wherein the (a), (b), and (c) are configured so that the laser illumination originates the same side of the stage or substrate as the injector opening and wherein the centerline of the laser illumination and the orientation of plume expansion are substantially transverse to the centerline of the injector lumen.
2 more elements
Dependencies are inferred from the claim text.