Methods Of Identifying Subjects Having An Increased Risk Of Developing A Coronavirus Infection And Treatment Thereof

A method of treating a subject with a therapeutic agent that treats or inhibits a coronavirus infection, wherein the subject is suffering from a coronavirus infection or is susceptible to developing a coronavirus infection, the method comprising the steps of:

• determining a polygenic risk score (PRS) for the subject by:
• obtaining or having obtained a biological sample from the subject;
• and
• performing or having performed a genotyping assay on the biological sample to determine if the subject has a genotype comprising one or more genetic variants associated with susceptibility to developing a coronavirus infection and/or associated with severity of a coronavirus infection;
• wherein the PRS score reflects the presence or absence of the genetic variants and the homozygosity and heterozygosity of the subject for each of the genetic variants;
• when the subject has a PRS score below a desired threshold, then administering or continuing to administer to the subject the therapeutic agent that treats or inhibits the coronavirus infection in a standard dosage amount and/or monitoring the subject for initiation of the coronavirus infection and/or increasing severity of the coronavirus infection;
• and
• when the subject has a PRS score above a desired threshold, then administering or continuing to administer to the subject the therapeutic agent that treats or inhibits the coronavirus infection in an amount that is the same as or greater than a standard dosage amount;
• wherein the presence of a PRS score above the desired threshold indicates the subject has an increased risk of developing the coronavirus infection and/or has an increased risk of developing a severe coronavirus infection.