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OwnerMathieu Bakhoum, Samuel Bakhoum +2inventors
InventorsMathieu Bakhoum, Samuel Bakhoum, Paul Mischel, Ashley Laughney
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Provided herein are methods for treating uveal melanoma in a subject in need thereof, and methods of detecting high-risk uveal melanoma in a subject, the subject having been selected by a method comprising, or alternatively consisting essentially of, or yet further consisting of detection of high methyl ati on levels at one or more of: BAP-1, CCNG2 and/or FKBP14 and/or measuring the mRNA expression of JARID2 and TMEM173 and determining ratio of mRNA expression JARID2 to TMEM173 in a sample isolated from the subject. Further provided herein are methods of determining prognosis of a subject having uveal melanoma, wherein high methylation levels and/or the ratio of mRNA expression JARID2 to TMEM173 of less than about 1 indicate a decreased probability and/or duration of survival and low methylation levels and/or the ratio of mRNA expression JARID2 to TMEM173 of greater than about 1 indicate an increased probability and/or duration of survival.
A method for treating a high-risk uveal melanoma in a subject having one or more in a sample isolated from the subject:
A method for detecting high-risk uveal melanoma in a subject, comprising detecting high methylation levels at one or more of:
-10. (canceled)
A method of determining prognosis of a subject having uveal melanoma, comprising detecting methylation levels at one or more of:
-27. (canceled)
A method of treating a subject having uveal melanoma (UM), wherein the subject has one or more of:
-30. (canceled)
(canceled)
-37. (canceled)
A method comprising quantifying a methylation level of a loci in a sample isolated from a subject, wherein the loci comprises one or more of the loci identified in Table 2 and/or 7 and/or the loci within one or more of the following genes:
-51. (canceled)
Dependencies are inferred from the claim text.