Apparatus, system and method
AssigneeNanovery Limited
InventorsJerzy KOZYRA, Mun Ching LEE
Life of this patent
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Abstract
A DNA nano device (2) and a method of producing a DNA nano device (2) for detecting a biomarker are provided. The DNA nano device (2) includes an ensemble of DNA formations. The formations include a detector (4) adapted to accept a target biomarker and thereby to release a trigger DNA sequence; an amplifier (6) adapted for hybridisation with the trigger DNA sequence which thereby releases a key DNA sequence and the trigger DNA sequence or a further trigger DNA sequence; and a responder (8) adapted for hybridisation with the key DNA sequence and thereby to produce a signal. The DNA nano device (2) thereby produces a signal detectable to an observer in response to the detection of the target biomarker.
Claims25
An ensemble of DNA formations for detecting a biomarker, the formations including:
- a detector adapted to accept a target biomarker and thereby to release a trigger DNA sequence;
- an amplifier adapted for hybridisation with the trigger DNA sequence and thereby to release a key DNA sequence and the trigger DNA sequence or a further trigger DNA sequence;
- and
- a responder adapted for hybridisation with the key DNA sequence and thereby to cause a signal detectable to an observer to be produced.
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A method of detecting a target biomarker, comprising:
- hybridising a target biomarker to a probe and thereby releasing a trigger DNA sequence;
- hybridising the trigger DNA sequence to an amplifier DNA sequence and thereby causing one or more conformational changes of the amplifier DNA sequence, releasing a key DNA sequence, and releasing a trigger DNA sequence;
- and
- hybridising the key DNA sequence to a lock DNA sequence portion of a DNA capture formation and thereby cause a signal detectable to an observer to be produced, preferably by changing configuration of the DNA capture formation to release a reporter.
(canceled)
Dependencies are inferred from the claim text.