US 2022/0177969 A1 · Methods for Detecting an increased risk for coronary heart disease

Abstract

The invention relates generally to an allele on human chromosome 9 associated with increased risk for coronary heart disease and the use or detection of such an allele in determining whether a human has an increased risk for coronary heart disease. In one aspect, the invention relates to methods for detecting a predisposition or propensity or susceptibility for coronary heart disease in a human, comprising detecting the presence of an allele on human chromosome 9 that is associated with an increased risk for coronary heart disease in a human. Disclosed are methods and compositions for determining whether a person carries an allele associated with increased risk for coronary atherosclerosis by determining whether the person has an RA-CHR9 allele, such as by determining whether the person has an RA-CHR9 allele-associated single nucleotide polymorphism (SNP). The invention also relates to kits for detecting the presence of an allele on chromosome 9 associated with an increased risk for coronary heart disease.

Claims20

Dependent claims

A method for determining treatment of a person for increased risk for coronary heart disease, the method comprising steps:

obtaining a blood sample from the person;
isolating DNA from the blood sample;
performing chip-based oligonucleotide hybridization with a chip configured to detect a genetic marker that is a “G” allele at the polymorphic position defined by rs10757274, thereby detecting the presence or absence of the genetic marker in the DNA, to provide genetic information of the person;
diagnosing the person as having an increased risk for coronary heart disease if the maker is present, and as not having an increased risk for coronary heart disease if the marker is absent, to provide diagnostic information for the person;
determining based on the diagnostic information a suitable therapy for the person to delay the onset, prevent the onset or slow progression of coronary heart disease, to provide therapeutic information for the person;
and
providing the diagnostic information and the therapeutic information to the person or a healthcare provider for treating the person according to the diagnostic information and the therapeutic information.

4 more elements

Dependencies are inferred from the claim text.

Methods for Detecting an increased risk for coronary heart disease

Life of this patent

Methods for Detecting an increased risk for coronary heart disease

Life of this patent

Abstract

Claims20