Compounds to Identify Beta-Lactamases, and Methods of Use Thereof

A compound having the structure of Formula I or Formula II:

• or a salt, stereoisomer, tautomer, polymorph, or solvate thereof, wherein:
• T1 is a benzenethiol containing group or Z2, wherein if T1 is Z2, then Z1 is T2;
• Z1 is a carboxylate, a carbonyl, an ester, an amide, a sulfone, a sulfonamide, a sulfonyl, —S(O)2OH or T2, wherein if Z1 is T2, then T1 is Z2;
• T2 is a benzenethiol containing group;
• T3 is a benzenethiol containing group;
• Z2 is a carboxylate, a carbonyl, an ester, an amide, a sulfone, a sulfonamide, a sulfonyl, or —S(O)2OH;
• Z3 is a carboxylate, a carbonyl, an ester, an amide, a sulfone, a sulfonamide, a sulfonyl, or —S(O)2OH;
• X1 is
• Y1 is
• Y2 is
• R1-R6, R9-R11, R13 and R14 are each independently selected from H, D, hydroxyl, nitrile, halo, amine, nitro, amide, thiol, aldehyde, carboxylic acid, alkoxy, optionally substituted (C1-C4) ester, optionally substituted (C1-C4) ketone, optionally substituted (C1-C6)alkyl, optionally substituted (C1-C6)alkenyl, optionally substituted (C1-C6)alkynyl, optionally substituted (C5-C7) cycloalkyl, optionally substituted aryl, optionally substituted benzyl, and optionally substituted heterocycle;
• R7 is an optionally substituted (C5-C7) cycloalkyl, optionally substituted aryl, optionally substituted benzyl, or optionally substituted heterocycle;
• and
• R8 is
• with the proviso that the compound does not have the structure of: