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AssigneesNational University Corporation Tokyo Medical and Dental University, Sysmex Corporation
InventorsHiroshi ASAHARA, Ryota KURIMOTO, Takahide MATSUSHIMA, Hiroki TSUTSUMI
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One of the purposes of the present invention is to provide a method for producing a gene-edited tissue stem cell in an undifferentiated state within a short period of time. Another one of the purposes of the present invention is to provide a method for treating and/or preventing a disease using a gene-edited tissue stem cell in an undifferentiated state. A gene-edited tissue stem cell is produced by a method comprising a step for editing the gene sequence of a target gene in tissue stem cells, and a step for selecting the tissue stem cells having an edited gene sequence, and optionally, further comprising a step for adding a tag to the gene sequence of the target gene and/or a step for activating gene expression of the target gene in the tissue stem cells. The tissue stem cell thus produced is used in treating/preventing diseases.
A method for producing a gene-edited tissue stem cell, comprising editing the gene sequence of a target gene in the tissue stem cell and selecting the tissue stem cell with the edited gene sequence.
A therapeutic agent for the treatment of a hematological disease or an immunological disease, comprising hematopoietic stem cells within 48 hours of isolation from an organism in which the gene sequence of the target gene has been edited.
A method for producing a gene-edited tissue stem cell, comprising editing the gene sequence of the target gene in the tissue stem cell,
Dependencies are inferred from the claim text.