Hipk inhibitors and methods of use thereof
AssigneesBoard of Regents, The University of Texas System, Vibliome Therapeutics, LLC
InventorsQiang SHEN, Gary A. FLYNN
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Abstract
Method of treating cancer, such as a metastatic cancer, with inhibitors of homeodomain interacting protein kinase 4 (HIPK4) are provided. Related therapeutic compositions are also disclosed.
Claims39
A method of treating cancer in a subject comprising administering an effective amount of an inhibitor of homeodomain interacting protein kinase 4 (HIPK4) to the subject.
A method of treating a subject having a cancer comprising:
- (a) obtaining a sample from the subject,
- (b) determining the level of homeodomain interacting protein kinase 4 (HIPK4) expression or kinase function in the sample;
- and
- (c) administering an effective amount of an inhibitor of HIPK4 to a subject determined to have an elevated level of HIPK4 expression or kinase function.
A method of predicting a response to an inhibitor of HIPK4 in a subject having a cancer comprising detecting the level of HIPK4 expression or kinase function in a tissue sample obtained from the subject, wherein if the sample exhibits increased expression or kinase activity of HIPK4, then the subject is predicted to have a favorable response to a HIPK4 inhibitor therapy.
Dependencies are inferred from the claim text.