Back to results
US 2022/0177867 A1Published application
Novel botulinum neurotoxin and its derivatives
AssigneeChildren's Medical Center Corporation
InventorsMin Dong, Sicai Zhang, Paul Stenmark
Life of this patent
Estimating the term…
Abstract
Provided herein are Clostridial Botulinum neurotoxin (BoNT) polypeptides of a novel serotype (BoNT/X) and methods of making and using the BoNT polypeptides, e.g., in therapeutic applications.
Claims21
-175. (canceled)
A chimeric Clostridial Botulinum neurotoxin (BoNT) polypeptide comprising:
- (a) a protease domain;
- (b) a linker region;
- (c) a translocation domain;
- and
- (d) a receptor binding domain,
- wherein (a) and (c) are from BoNT serotype X, and wherein (d) is not from BoNT serotype X.
3 more elements
Dependencies are inferred from the claim text.