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US 2022/0177863 A1Published application
Type vii crispr proteins and systems
AssigneesThe Broad Institute, Inc., Massachusetts Institute of Technology
InventorsFeng Zhang, Han Altae-Tran
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Abstract
The present application provides systems, methods and compositions used for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of Type VII Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and transposable elements.
Claims50
An engineered system, comprising:
- a Type VII CRISPR effector protein,
- wherein the Type VII CRISPR effector protein is capable of complexing with a crRNA to form a CRISPR-Cas complex, wherein the crRNA comprises a direct repeat (DR) sequence and a guide sequence capable of hybridizing to a target nucleic acid sequence.
The gene product of aspect 49, wherein the amount of gene product expressed is greater than or less than the amount of gene product from a cell that does not have altered expression.
Dependencies are inferred from the claim text.