Precise Gene Activation Via Novel Designed Proteins Mediating Epigenetic Remodeling
OwnerShiri LEVY, Hannele RUOHOLA-BAKER +1inventors
InventorsShiri LEVY, Hannele RUOHOLA-BAKER, David BAKER
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Abstract
Disclosed herein are compositions including an embryonic ectoderm development (BED) polypeptide binder (EB) domain and a CRISPR associated protein 9 (CAS9) domain linked to the EB domain, and uses thereof for gene activation in a biological cell.
Claims34
A composition, comprising:
- (a) an embryonic ectoderm development (EED) polypeptide binder (EB) domain;
- and
- (b) a CRISPR associated protein 9 (CAS9) domain linked to the EB domain.
A pharmaceutical composition comprising the composition, nucleic acid, expression vector, and/or host cell of any previous claim and a pharmaceutically acceptable carrier.
A method for use of the composition, the nucleic acid, the expression vector, the host cell, the pharmaceutical composition, and/or the kit of any preceding claim for gene activation in a biological cell.
Dependencies are inferred from the claim text.