Method for inducing direct reprogramming of urine cell into renal progenitor cell and pharmaceutical composition containing reprogrammed renal progenitor cell

A method of inducing direct reprogramming of urine cells into renal progenitor cells, comprising:

• (a) culturing urine cells isolated from urine;
• (b) introducing reprogramming factors such as i) a nucleic acid encoding an Oct4 protein, ii) a nucleic acid encoding an Sox2 protein, iii) a nucleic acid encoding art Klf4 protein, and iv) a nucleic acid encoding an c-Myc protein and v) a nucleic acid encoding a Slug protein into the cultured urine cells;
• (c) culturing the reprogramming factor-introduced urine cells in a renal progenitor cell culture medium to induce reprogramming into renal progenitor cells;
• and
• (d) selecting the reprogrammed renal progenitor cells having the characteristics of renal progenitor cells from the cells in which direct reprogramming into renal progenitor cells is induced.