Platform for generating safe cell therapeutics
AssigneeThe Regents of the University of California
InventorsRichard KLEMKE, Huawei WANG
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Abstract
Provided herein are cytoplasts, compositions comprising cytoplasts, methods of using cytoplasts, and methods of treating a subject, such as providing benefits to a healthy or unhealthy subject, or treating or diagnosing a disease or condition in a subject. In some embodiments, methods of treating a subject include: administering to the subject a therapeutically effective amount of a composition comprising a cytoplast. Also, provided herein are compositions (e.g., pharmaceutical compositions) that include a cytoplast. Also, provided herein are kits comprising instructions for using the compositions or methods.
Claims30
A method for treating cancer or a neoplasm in a subject, the method comprising:
- administering to a subject a cell without a nucleus, wherein the cell without the nucleus comprises a virus, wherein the virus comprises an exogenous nucleic acid molecule comprising a sequence encoding a therapeutic agent for the treatment of the cancer or the neoplasm, wherein the cell without the nucleus delivers the virus to a cancer cell or a neoplasm cell in the subject, thereby treating the cancer or the neoplasm in the subject.
Dependencies are inferred from the claim text.