Genome-edited induced pluripotent stem cells, and cells derived therefrom, and uses thereof
AssigneeThe University of Queensland
InventorsNathan PALPANT, Meredith Ann REDD
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Abstract
This invention relates to compositions and uses of genome edited iPSCs and cells derived therefrom. In particular the iPSCs and cells derived therefrom and compositions comprising the same according to the present invention may be used in cell-based therapies for tissue repair or regeneration. The invention relates to the treatment and/or prevention of injury to the myocardium, and/or ischemia reperfusion injury in the myocardium and other vascularized tissues.
Claims20
A composition comprising cells differentiated in vitro from stem cells which have been genetically modified to lack, or have decreased or disrupted expression and/or activity of ASIC1a.
A method of transplanting in vitro-differentiated human mesodermal lineage cells, the method comprising transplanting into or onto a tissue or organ of a subject in vitro-differentiated human mesodermal lineage cells that have been derived from stem cells which have been genetically modified to lack or have decreased expression and/or activity of ASIC1a.
A method of promoting survival and/or engraftment of transplanted human, in vitro-differentiated cardiomyocytes, the method comprising administering to a subject in need thereof in vitro-differentiated cardiomyocytes that have been derived from stem cells which have been genetically modified to lack or have decreased expression and/or activity of ASIC1a.
Dependencies are inferred from the claim text.