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US 2022/0177618 A1Published application
Medical device and method for manufacturing same
AssigneeTerumo Kabushiki Kaisha
InventorsMasanori KURAMOTO, Narumi YOKOTE
Life of this patent
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Abstract
A medical device includes: a substrate layer; an adhesive layer on at least a part of the substrate layer and containing a hydrophilic copolymer (1) containing a structural unit derived from a polymerizable monomer (A) having a sulfobetaine structure, a structural unit derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group (—SO3H), a sulfuric acid group (—OSO3H), a sulfurous acid group (—OSO2H), and salt groups thereof, and a structural unit derived from a polymerizable monomer (C) having a photoreactive group; and a surface lubricious layer formed on at least a part of the adhesive layer and containing a hyaluronic acid or a salt thereof and a hydrophilic copolymer (2).
Claims20
A medical device, comprising:
- a substrate layer;
- an adhesive layer formed on at least a part of the substrate layer, the adhesive layer containing:
- a hydrophilic copolymer (1) containing (i) a structural unit derived from a polymerizable monomer (A) having a sulfobetaine structure, (ii) a structural unit derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group, a sulfuric acid group, a sulfurous acid group, and salt groups thereof, and (iii) a structural unit derived from a polymerizable monomer (C) having a photoreactive group;
- and
- a surface lubricious layer formed on at least a part of the adhesive layer, the surface lubricious layer containing a hyaluronic acid or a salt thereof and a hydrophilic copolymer (2) containing (i) a structural unit derived from a polymerizable monomer (A′) having a sulfobetaine structure, (ii) a structural unit derived from a polymerizable monomer (B′) having at least one group selected from the group consisting of a sulfonic acid group, a sulfuric acid group, a sulfurous acid group, and salt groups thereof, and (iii) a structural unit derived from a polymerizable monomer (C′) having a photoreactive group.
2 more elements
A medical device, comprising:
- a substrate layer;
- an adhesive layer formed on at least a part of the substrate layer, the adhesive layer containing a hydrophilic copolymer (1) containing (i) a structural unit derived from a polymerizable monomer (A) having a sulfobetaine structure, (ii) a structural unit derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group, a sulfuric acid group, a sulfurous acid group, and salt groups thereof, and (iii) a structural unit derived from a polymerizable monomer (C) having a photoreactive group;
- and
- a surface lubricious layer formed on at least a part of the adhesive layer, the surface lubricious layer containing (a) at least one water-retaining material selected from the group consisting of a polyelectrolyte, a polysaccharide, and a nonionic polymer, and (b) a hydrophilic copolymer (2) containing (i) a structural unit derived from a polymerizable monomer (A′) having a sulfobetaine structure, (ii) a structural unit derived from a polymerizable monomer (B′) having at least one group selected from the group consisting of a sulfonic acid group, a sulfuric acid group, a sulfurous acid group, and salt groups thereof, and (iii) a structural unit derived from a polymerizable monomer (C′) having a photoreactive group.
1 more element
A method comprising:
- inserting a medical device into a lumen in a living body, the medical device comprising:
- a substrate layer;
- an adhesive layer formed on at least a part of the substrate layer, the adhesive layer containing:
- a hydrophilic copolymer (1) containing (i) a structural unit derived from a polymerizable monomer (A) having a sulfobetaine structure, (ii) a structural unit derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group, a sulfuric acid group, a sulfurous acid group, and salt groups thereof, and (iii) a structural unit derived from a polymerizable monomer (C) having a photoreactive group;
- a surface lubricious layer formed on at least a part of the adhesive layer, the surface lubricious layer containing a water-retaining material and a hydrophilic copolymer (2);
- the water-retaining material being either;
- i) a hyaluronic acid or a salt thereof;
- or ii) selected from the group consisting of a polyelectrolyte, a polysaccharide, and a nonionic polymer;
- and
- the hydrophilic copolymer (2) containing (i) a structural unit derived from a polymerizable monomer (A′) having a sulfobetaine structure, (ii) a structural unit derived from a polymerizable monomer (B′) having at least one group selected from the group consisting of a sulfonic acid group, a sulfuric acid group, a sulfurous acid group, and salt groups thereof, and (iii) a structural unit derived from a polymerizable monomer (C′) having a photoreactive group;
- and
- moving the medical device in the lumen in the living body, whereby aqueous liquid in the lumen contacts and wets the surface lubricious layer so that the surface lubricious layer exhibits a lubricating property.
9 more elements
Dependencies are inferred from the claim text.