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US 2022/0177605 A1Published application
Chemically induced protein dimerization systems
AssigneeUniversity of Washington
InventorsLiangcai GU, Shoukai KANG, Luis GOMEZ-CASTILLO, Huayi JIANG
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Abstract
The disclosure provides polypeptides, fusion proteins, kits, dimers, nucleic acids, expression vectors, or host cells for use hi chemically induced dimerization systems, exemplified by a chemically induced dimerization system in which two recombinant antibodies dimerize only in the presence of cannabidiol.
Claims22
A recombinant antibody, comprising a set of complementarity-determining regions (CDRs) selected from the group consisting of a CDR1, CDR2, and CDR3 combination in any one of rows (a)-(aa) in Table 1.
A fusion protein, comprising:
- (a) a first recombinant antibody, comprising the set of complementarity determining regions (CDRs) of SEQ ID NO:1, 2, and 3;
- (b) a second recombinant antibody, comprising a set of complementarity determining regions (CDRs) selected from the group consisting of a CDR1, CDR2, and CDR3 combination in any one of rows (d)-(aa) in Table 1;
- and
- (c) a linker between the first antibody and the second antibody.
1 more element
A kit, comprising:
- (a) a first recombinant antibody, comprising the set of complementarity determining regions (CDRs) of SEQ ID NO:1, 2, and 3;
- (b) a second recombinant antibody, comprising a set of complementarity determining regions (CDRs) selected from the group consisting of a CDR1, CDR2, and CDR3 combination in any one of rows (d)-(aa) in Table 1;
- and
- (c) cannabidiol, or a salt thereof.
1 more element
-19. (canceled)
-29. (canceled)
Dependencies are inferred from the claim text.