ANTI-IgE ANTIBODIES
Assigneeargenx IIP BV
InventorsMichael SAUNDERS, Rene BIGIRIMANA, Christophe BLANCHETOT, Marijn CROMHEECKE, Conor MCGUIRE
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Abstract
The present invention relates to antibodies that bind to IgE and their use in the treatment of autoimmune diseases, particularly Bullous Pemphigoid (BP) and Chronic Spontaneous Urticaria (CSU). The anti-IgE antibodies comprise a variant Fc domain that binds to the Fc receptor FcRn with increased affinity relative to a wild-type Fc domain. The anti-IgE antibodies may comprise a variant Fc domain comprising the amino acids Y, T, E, K, F and Y at EU positions 252, 254, 256, 433, 434 and 436, respectively, wherein the variant Fc domain binds to human FcRn with increased affinity relative to a wild-type human IgG Fc domain.
Claims76
An antibody that binds to IgE, wherein the antibody comprises a variant Fc domain or a FcRn binding fragment thereof that binds to FcRn with increased affinity relative to a wild-type Fc domain.
An antibody that binds to IgE, wherein the antibody comprises a variant Fc domain or a FcRn binding fragment thereof, said variant Fc domain or FcRn binding fragment comprising the amino acids Y, T, E, K, F and Y at EU positions 252, 254, 256, 433, 434 and 436, respectively.
Dependencies are inferred from the claim text.