Single domain antibody and derivative proteins thereof against ctla4
AssigneesXitian Zhang, Xin Zhang, Suzhou Alphamab Co., Ltd.
InventorsTing Xu, Xiaoxiao Wang, Jie Li, Haiyan Wu, Li Gao, Qian Chu, Yu Bai
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Abstract
The present invention relates to the field of medical biology, and discloses a single domain antibody and derivative proteins thereof against CTLA4. In particular, the present invention discloses a CTLA4 binding protein and the use thereof, especially the use for treating and/or preventing CTLA4 relevant diseases such as tumor.
Claims27
A CTLA4-binding protein, which can specifically bind to CTLA4 and comprises at least one immunoglobulin single variable domain, said immunoglobulin single variable domain is a humanized VHH comprising an amino acid sequence of any one of SEQ ID NOs:106-109.
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Dependencies are inferred from the claim text.