Polypeptides comprising immunoglobulin single variable domains targeting il-13 and tslp

A nucleic acid comprising a nucleotide sequence that encodes a polypeptide that comprises at least one immunoglobulin single variable domain (ISVD) that specifically binds to IL13 or TSLP, wherein said ISVD comprises three complementarity determining regions (CDR1 to CDR3, respectively);

• and wherein the at least one ISVD comprises:
• a) a CDR1 that is the amino acid sequence of SEQ ID NO:
• 7;
• a CDR2 that is the amino acid sequence of SEQ ID NO:
• 12;
• and
• a CDR3 that is the amino acid sequence of SEQ ID NO:
• 17,
• b) a CDR1 that is the amino acid sequence of SEQ ID NO:
• 8;
• a CDR2 that is the amino acid sequence of SEQ ID NO:
• 13;
• and
• a CDR3 that is the amino acid sequence of SEQ ID NO:
• 18,
• c) a CDR1 that is the amino acid sequence of SEQ ID NO:
• 9;
• a CDR2 that is the amino acid sequence of SEQ ID NO:
• 14;
• and
• a CDR3 that is the amino acid sequence of SEQ ID NO:
• 19 or
• d) a CDR1 that is the amino acid sequence of SEQ ID NO:
• 11;
• a CDR2 that is the amino acid sequence of SEQ ID NO:
• 16;
• and
• a CDR3 that is the amino acid sequence of SEQ ID NO:
• 21.