Chimeric proteins and chimeric protein complexes directed to fms-like tyrosine kinase 3 (flt3)

The Fc-based chimeric protein complex of any one of the above claims, wherein the targeting moiety is directed against an immune cell, optionally being a dendritic cell.

The Fc-based chimeric protein complex of any one of the above claims, wherein the targeting moiety functionally modulates the antigen or receptor of interest.

The Fc-based chimeric protein complex of any one of the above claims, wherein the targeting moiety binds but does not functionally modulate the antigen or receptor of interest.

The Fc-based chimeric protein complex of any one of the above claims, wherein the targeting moiety directly or indirectly recruits immune cells to tumor cells or to the tumor microenvironment.

The Fc-based chimeric protein complex of any one of the above claims, wherein the targeting moiety increases a number of dendritic cells.

The Fc-based chimeric protein complex of any one of the above claims, wherein the targeting moiety enhances tumor antigen presentation, optionally by dendritic cells.

The Fc-based chimeric protein complex of any one of the above claims, further comprising an additional targeting moiety, optionally being two targeting moieties, which are identical or non-identical.

The Fc-based chimeric protein complex of any one of the above claims, comprising an additional signaling agent.

The Fc-based chimeric protein complex of any one of the above claims, comprising two signaling agents.

The Fc-based chimeric protein complex of any one of the above claims, wherein the Fc-based chimeric protein complex is suitable for use in a patient having one or more of:

• cancer, infections, immune disorders, autoimmune and/or neurodegenerative disease, cardiovascular diseases, wound, ischemia-related diseases, and/or metabolic diseases.

A method for treating or preventing a cancer, comprising administering an effective amount of the Fc-based chimeric protein complex of any one of the above claims to a patient in need thereof.

An Fc-based chimeric protein complex comprising:

• (i) one or more targeting moieties comprising a FMS-like tyrosine kinase 3 ligand (FLT3L) domain, wherein the FLT3L domain is a single chain dimer and
• (ii) an Fc domain, the Fc domain optionally having one or more mutations that reduces or eliminates one or more effector functions of the Fc domain, promotes Fc chain pairing in the Fc domain, and/or stabilizes a hinge region in the Fc domain.