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US 2022/0177529 A1Published application
Fusion protein for enhancing gene editing and use thereof
AssigneeBioray Laboratories Inc.
InventorsDali LI, Shuming YIN, Mei ZHANG, Xi CHEN, Xiaohui ZHANG, Liren WANG, Mingyao LIU
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Abstract
The present invention relates to a fusion protein for enhancing gene editing and use thereof. In particular, the invention provides an enhanced fusion protein. The enhanced fusion proteins of the present invention can significantly increase gene editing efficiency in vivo or in vitro as compared to the wildtype gene editing protein.
Claims20
A fusion protein, wherein the structure of the fusion protein is shown in the following Formula I or I′:
- C-A-L-B (I)
- B-L-A-C (I′)
- wherein
- A is a gene editing protein,
- B is a DNA double-strand binding domain,
- C is an optional base editor element;
- L is none or a linker peptide;
- and wherein
- each “-” is independently a linker peptide or a peptide bond or a non-peptide bond.
6 more elements
5-8. (canceled)
10-11. (canceled)
Dependencies are inferred from the claim text.