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US 2022/0177528 A1Published application
Chimeric antigen receptors containing a chlorotoxin domain
OwnerMichael Barish, Christine E. Brown +2inventors
InventorsMichael Barish, Christine E. Brown, Stephen J. Forman, Dongrui Wang
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Abstract
Chimeric transmembrane immunoreceptors (CAR) which include an extracellular domain that includes chlorotoxin or a related toxin, or a variant of chlorotoxin or a related toxin, that binds to human glioma or other human tumor cells, a transmembrane region, a costimulatory domain and an intracellular signaling domain are described.
Claims13
-32. (canceled)
A method for treating a malignant glioma comprising administering a therapeutically effective dose of T cells expressing a chimeric antigen receptor, wherein the chimeric antigen receptor comprises:
- chlorotoxin;
- a spacer domain, a transmembrane domain selected from:
- a CD4 transmembrane domain, a CD8 transmembrane domain, a CD28 transmembrane domain, and a CD3ζ transmembrane domain;
- a costimulatory domain;
- and CD3 ζ signaling domain.
2 more elements
Dependencies are inferred from the claim text.