Methods for producing crystalline l-glufosinate ammonium monohydrate
AssigneeBASF SE
InventorsBrian Michael Green, Rachel Melissa Witek, Nadejda Pavlova, Matthew Richard Oberholzer
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Abstract
Methods for preparing crystalline L-glufosinate ammonium monohydrate are disclosed. The methods include forming a mixture comprising water, a water-miscible organic solvent, ammonium hydroxide, and a glufosinate starting material containing L-glufosinate ammonium and D-glufosinate ammonium. L-Glufosinate ammonium monohydrate is crystallized and separated from the mixture, providing L-glufosinate ammonium monohydrate Form B. Compositions and methods employing the crystalline L-glufosinate ammonium monohydrate are also described.
Claims38
A method for preparing crystalline L-glufosinate ammonium monohydrate, the method comprising:
- (i) forming a mixture comprising a L-glufosinate starting material and an aqueous solution,
- wherein the glufosinate starting material comprises L-glufosinate ammonium and D-glufosinate ammonium, and
- wherein the aqueous solution comprises water and a water-miscible organic solvent;
- (ii) crystallizing L-glufosinate ammonium from the mixture of step (i) to form L-glufosinate ammonium monohydrate crystals;
- and
- (iii) separating at least a portion of the L-glufosinate ammonium monohydrate crystals from the aqueous solution following step (ii);
- thereby preparing the crystalline L-glufosinate ammonium monohydrate,
- wherein the crystalline L-glufosinate ammonium monohydrate comprises L-glufosinate ammonium monohydrate Form B.
A mutant D-amino acid oxidase enzyme wherein said enzyme comprises the sequence set forth in SEQ ID NO:
- 2.
A mutant D-amino acid oxidase enzyme wherein said enzyme comprises the sequence set forth in SEQ ID NO:
- 3.
A mutant D-amino acid oxidase enzyme wherein said enzyme comprises the sequence set forth in SEQ ID NO:
- 5.
Dependencies are inferred from the claim text.