Pyridinamine-pyridone and pyrimidinamine-pyridone compounds

A process for preparing a compound represented by Formula (I):

• wherein:
• R1 is phenyl or monocyclic 5-6 membered heteroaryl, each optionally substituted with one or more substituents selected from halogen, C1-C6alkyl, C3-C4cycloalkyl, C1-C6alkoxy, C1-C6haloalkyl, C1-C6haloalkoxy, amino, N—C1-C3alkylamino and N,N-diC1-C3alkylamino;
• R2 is selected from the group consisting of hydrogen, C1-C3haloalkyl and C1-C3alkyl;
• R3 is selected from the group consisting of A, phenyl and monocyclic heteroaryl, said phenyl and said heteroaryl being each optionally substituted with one or more of R4, R5, R6 and R7;
• R4, R5, R6 and R7 are independently selected from halogen, C1-C6alkyl, C3-C4cycloalkyl, C1-C6alkoxy, C1-C6haloalkyl, C1-C6haloalkoxy, azetidine, amino, N—C1-C3alkylamino, N,N-diC1-C3alkylamino, NHSO2R′, SO2R9 and hydroxy;
• R8 is C1-C3haloalkyl or C1-C3alkyl;
• R9 is selected from the group consisting of R10, C1-C6alkyl, amino, N—C1-C3alkylamino, N,N-diC1-C3alkylamino and C1-C3alkoxyC1-C3alkyl, wherein said C1-C6alkyl and C1-C3alkoxyC1-C3alkyl being each optionally substituted with one R10 and/or one or more halogen;
• R10 is selected from the group consisting of phenyl, benzyl, monocyclic heteroaryl, C3-C6cycloalkyl, heterocyclyl, each optionally substituted with one or more R11;
• R11 is selected from the group consisting of halogen, C1-C3haloalkyl, C3-C4cycloalkyl, C1-C3alkyl, amino, N—C1-C3alkylamino, N,N-diC1-C3alkylamino and C1-C3alkoxyC1-C3alkyl;
• A is
• R12 is selected from the group consisting of hydrogen, halogen, COR13, C1-C6alkyl, C3-C6cycloalkyl, C1-C3alkoxyC1-C3alkyl, C1-C6alkoxy, C3-C6cycloalkyl, C1-C3cyanoalkyl, and C1-C3haloalkyl;
• R13 is selected from the group consisting of C1-C3alkoxy, N—C1-C3alkylamino, N,N-diC1-C3alkylamino, 1-pyrrolidinyl, 1-piperidinyl and 1-azetidinyl;
• Y is selected from the group consisting of CH2, S, SO, S02, NR14, NCOR9, NCOOR15, NSO2R9, NCOCH2R9, O, or a bond;
• R14 is selected from the group consisting of H, C1-C3haloalkyl, C1-C3alkoxyC1-C3alkyl, C1-C3alkyl, and C3-C6cycloalkyl;
• R15 is selected from the group consisting of R10, C1-C6alkyl and C1-C3alkoxyC1-C3alkyl, and wherein said C1-C6alkyl and C1-C3alkoxyC1-C3alkyl being each optionally substituted with one R10 and/or one or more halogen;
• and
• Z is CH or N;
• or a pharmaceutically acceptable salt thereof;
• the process comprising:
• (i) providing a compound represented by Formula (III):
• wherein:
• R1, R2, R3, and Z are defined as above for Formula (I);
• and
• RX is selected from the group consisting of F, OCH3, OC(CH3)3, and OSiR′R″R′″;
• and
• R′, R″, and R′″ are each independently aryl or alkyl;
• and
• (ii) converting the compound represented by Formula (III) into the compound represented by Formula (I).