Fused polycyclic pyridone compounds as influenza virus replication inhibitors

A compound of Formula (IA):

• wherein:
• W is hydrogen, halo, alkyl, cyano, carboxy, alkoxycarbonyl, aminocarbonyl,
• alkylaminocarbonyl, dialkylaminocarbonyl, hydroxy, haloalkoxy, or alkyl substituted with one or two groups independently selected from halo, hydroxy, alkoxy, amino, alkylamino, and dialkylamino;
• R2 is hydrogen, halo, alkyl, haloalkoxy, hydroxy, or alkyl substituted with one, two, or three groups independently selected from halo, CN, hydroxy, alkoxy, amino, alkylamino, and dialkylamino;
• R3 is hydrogen, —C(O)R6, —C(O)—O—R7, —C(R8R9)—O—C(O)R10, —C(R11R12)—O—C(O)—OR13,
• —P(═O)(OR14)(OR15), —(CR16R17)—O—P(═O)(OR18)(OR19), —C(O)—N(R20R21), or —C(R22R21)—O—C(O)N(R24R25) where R6, R7, R10, R13, R14, R15, R18, R19, R20, R21, R24 and R25 are independently hydrogen, alkyl, phenyl, pyridyl, cycloalkyl, and a 3-6 membered heterocyclic ring wherein alkyl, phenyl, pyridyl, cycloalkyl, and a 3-6 membered heterocyclic ring are independently optionally substituted with one or two substituents independently selected from halo, cyano, hydroxy, amino, alkyl, carboxy, alkoxycarbonyl, phenyl, alkoxy, haloalkyl, and haloalkoxy;
• and R8, R9, R11, R12, R16, R17, R22, and R23 are independently hydrogen or alkyl:
• R4 and R5 together with the atoms to which they are attached form a ring of formula (a), (b), (c), or (d):
• wherein ring of formula (a), (b), (c), or (d) can optionally be substituted with one or two substituents independently selected from alkyl, alkoxy, hydroxy, halo, haloalkyl, haloalkoxy, and cyano;
• and
• Z is:
• (i) a ring of formula (i):
• where:
• wherein X is CH2, S, S(O), S(O)2, or O;
• and ring of formula (i) is substituted with one, two, three, or four substituents independently selected from hydrogen, halo, alkyl, haloalkyl, alkoxy, haloalkoxy, alkynyl, and cyano;
• or
• (ii) a ring of formula (ii):
• wherein Ar1 and Ar2 are independently selected from phenyl and a 5-6 membered heteroaryl ring containing 1-3 heteroatoms independently selected from N, O and S wherein each of the Ar1 and Ar2 is independently optionally substituted with one, two, or three substituents independently selected from halo, alkyl, haloalkyl, alkoxy, haloalkoxy, alkynyl, and cyan;
• or
• a pharmaceutically acceptable salt thereof.