Tyk2 inhibitors and uses thereof

A compound of Formula (II):

• a pharmaceutically acceptable salt or stereoisomer thereof, wherein:
• L is a 4-10 atom linker;
• optionally substituted with one or more RL;
• each RL is independently deuterium, halogen, —CN, —OR, —SRb, —S(═O)Ra, —S(═O)2Ra, —NO2, —NRcRd, —NHS(═O)2Ra, —S(═O)2NRcRd, —C(═O)Ra, —OC(═O)Ra, —C(═O)OR, —OC(═O)OR, —C(═O)NRcRd, —OC(═O)NRcRd, —NRbC(═O)NRcRd, —NRbC(═O)Ra, —NRbC(═O)OR, C1-C6alkyl, C1-C6haloalkyl, C1-C6deuteroalkyl, C1-C6hydroxyalkyl, C1-C6aminoalkyl, C2-C6alkenyl, C2-C6alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
• or two RL on the same carbon are taken together to form an oxo, a cycloalkyl, or heterocycloalkyl;
• or two RL on different carbons are taken together to form a cycloalkyl or heterocycloalkyl;
• Ring A is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
• each RA is independently deuterium, halogen, —CN, —OR, —SRb, —S(═O)Ra, —S(═O)2Ra, —NO2, —NRcRd, —NHS(═O)2Ra, —S(═O)2NRcRd, —C(═O)Ra, —OC(═O)Ra, —C(═O)OR, —OC(═O)OR, —C(═O)NRcRd, —OC(═O)NRcRd, —NRbC(═O)NRcRd, —NRbC(═O)Ra, —NRbC(═O)OR, C1-C6alkyl, C1-C6haloalkyl, C1-C6deuteroalkyl, C1-C6hydroxyalkyl, C1-C6aminoalkyl, C2-C6alkenyl, C2-C6alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
• wherein each alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more RA1;
• or two RA on the same carbon are taken together to form an oxo;
• each RA1 is independently deuterium, halogen, —CN, —OR, —SRb, —S(═O)Ra, —S(═O)2Ra, —NO2, —NRcRd, —NHS(═O)2Ra, —S(═O)2NRcRd, —C(═O)Ra, —OC(═O)Ra, —C(═O)OR, —OC(═O)OR, —C(═O)NRcRd, —OC(═O)NRcRd, —NRbC(═O)NRcRd, —NRbC(═O)Ra, —NRbC(═O)OR, C1-C6alkyl, C1-C6haloalkyl, C1-C6deuteroalkyl, C1-C6hydroxyalkyl, C1-C6aminoalkyl, C2-C6alkenyl, C2-C6alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
• or two RA1 on the same carbon are taken together to form an oxo
• n is 0-4;
• is a single bond or a double bond;
• X1 and X2 are —N— or —C═;
• provided that one of X1 or X2 is —N— and the other is —C═;
• Y8 is CR8 or N;
• Y6 is CR6 or N;
• Y3 is CR3 or N;
• Y9 is CR9 or N;
• R3, R6, R8, and R9 are independently hydrogen, deuterium, halogen, —CN, —OR, —SRb, —S(═O)Ra, —S(═O)2Ra, —NO2, —NRcRd, —NHS(═O)2Ra, —S(═O)2NRcRd, —C(═O)Ra, —OC(═O)Ra, —C(═O)OR, —OC(═O)OR, —C(═O)NRcRd, —OC(═O)NRcRd, —NRbC(═O)NRcRd, —NRbC(═O)Ra, —NRbC(═O)OR, C1-C6alkyl, C1-C6haloalkyl, C1-C6deuteroalkyl, C1-C6hydroxyalkyl, C1-C6aminoalkyl, C2-C6alkenyl, or C2-C6alkynyl;
• R4 is hydrogen, C1-C6alkyl, C1-C6heteroalkyl, C1-C6haloalkyl, C1-C6deuteroalkyl, C1-C6hydroxyalkyl, C1-C6aminoalkyl, C2-C6alkenyl, C2-C6alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
• wherein each alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are optionally substituted with one or more R4a;
• each R4a is independently deuterium, halogen, —CN, —OR, —NRcRd, —C(═O)Ra, —C(═O)OR, —C(═O)NRcRd, C1-C6alkyl, C1-C6haloalkyl, C1-C6deuteroalkyl, C1-C6hydroxyalkyl, C1-C6aminoalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
• or two R4a on the same carbon are taken together to form an oxo;
• R5 is hydrogen, C1-C6alkyl, C1-C6haloalkyl, or C1-C6deuteroalkyl;
• R7 is hydrogen, C1-C6alkyl, C1-C6haloalkyl, or C1-C6deuteroalkyl;
• each Ra is independently C1-C6alkyl, C1-C6haloalkyl, C1-C6deuteroalkyl, C1-C6hydroxyalkyl, C1-C6aminoalkyl, C2-C6alkenyl, C2-C6alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
• wherein each alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH2, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C1-C6alkyl, or C1-C6haloalkyl;
• each Rb is independently hydrogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6deuteroalkyl, C1-C6hydroxyalkyl, C1-C6aminoalkyl, C2-C6alkenyl, C2-C6alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
• wherein each alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH2, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C1-C6alkyl, or C1-C6haloalkyl;
• and
• each Rc and Rd is independently hydrogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6deuteroalkyl, C1-C6hydroxyalkyl, C1-C6aminoalkyl, C2-C6alkenyl, C2-C6alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
• wherein each alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH2, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C1-C6alkyl, or C1-C6haloalkyl;
• or Rc and Rd are taken together with the nitrogen atom to which they are attached to form a heterocycloalkyl optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH2, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C1-C6alkyl, or C1-C6haloalkyl.