N-1 branched alkyl substituted imidazo[4,5-c]quinoline compounds, compositions, and methods
Assignee3M Innovative Properties Company
InventorsGeorge W. Griesgraber, Michael J. Rice, Hannah C. Cohen, Devon M. Hunerdosse, Adam D. Miller, Joshua R. Wurst
Life of this patent
Estimating the term…
Abstract
Imidazo[4,5-c]quinoline compounds having a substituent that is attached at the N-1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing (or inhibiting) cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.
Claims16
A compound of Formula (II), or salt thereof:
- wherein:
- n is an integer of 0 or 1;
- R is selected from the group consisting of halogen, hydroxy, alkyl, alkoxy, and —C(O)—O-alkyl;
- R1 is a C1-6alkyl;
- R2 is selected from the group consisting of hydrogen, methyl, ethyl, n-propyl, n-butyl, —CH2OCH3, —CH2OCH2CH3, and —CH2CH2OCH3;
- R5 is selected from the group consisting of —H, —CH3, —F, and —OH;
- and
- R3 is a C1-4alkyl, R4 is a C1-4alkyl, or R3 and R4 are combined to form a ring of 3-7 carbon atoms, optionally having one oxygen atom in the ring, provided that R5 is not —OH.
(canceled)
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.