Degraders of kelch-like ech-associated protein 1 (keap1)

A bifunctional compound having a structure represented by formula:

• wherein the degron represents a moiety that binds an E3 ubiquitin ligase, and the linker represents a moiety that covalently connects the degron and the targeting ligand, or a pharmaceutically acceptable salt or stereoisomer thereof,
• wherein the KEAP1 targeting ligand is represented by formula TL1a or TL1b:
• wherein:
• R1 represents optionally substituted C1-C3 alkyl;
• R2 represents Me, OMe, or halo;
• R3 represents Me, OMe, or halo;
• X represents H and Y represents optionally substituted C1-C3 alkyl, or
• X represents O and Y represents optionally substituted CH2—CH2 and X and Y together with the atoms to which they are bound form a 7-membered cyclic sulfonamide;
• Ar represents a benzene or pyridine ring, or
• wherein the KEAP1 targeting ligand is represented by formula (TL2):
• wherein:
• R4 represents optionally substituted C1-C3 alkyl, OMe, or halo, or
• wherein the KEAP1 targeting ligand is represented by formula (TL3):
• wherein:
• R5 represents optionally substituted C1-C3 alkyl.