Back to results
US 2022/0177463 A1Published application
Pharmaceutical salts of benzothiazol compounds, polymorphs and methods for preparation thereof
Assignee1ST Biotherapeutics, Inc.
InventorsJinhwa LEE, Suyeon JO
Life of this patent
Estimating the term…
Abstract
The present disclosure provides polymorphic forms and salts of (1S,2S)-2-fluoro-N-(6-(4-methylpyridin-3-yl)benzo[d]thiazol-2-yl)cyclopropane-1-carboxamide, pharmaceutical compositions comprising the compounds, processes for preparation of the compounds, and methods for treating neurodegenerative disorders.
Claims14
A crystalline form of (1S,2S)-2-fluoro-N-(6-(4-methylpyridin-3-yl)benzo[d]thiazol-2-yl)cyclopropane-1-carboxamide or a pharmaceutically acceptable salt thereof,
- wherein the crystalline form is selected from the group consisting of:
- a crystalline form having peaks at diffraction angle (2θ) of 9.8±0.2, 11.6±0.2, 13.2±0.2, 14.0±0.2, 16.7±0.2, 17.6±0.2, 20.6±0.2, 22.9±0.2, 26.2±0.2, 29.3±0.2, 30.7±0.2, 31.6±0.2;
- a crystalline form having peaks at diffraction angle (2θ) of 6.0±0.2, 15.9±0.2, 18.1±0.2, 19.7±0.2, 24.6±0.2, 25.4±0.2, 26.7±0.2;
- a crystalline form having peaks at diffraction angle (2θ) of 8.7±0.2, 10.9±0.2, 12.9±0.2, 15.4±0.2, 16.4±0.2, 18.9±0.2, 20.3±0.2, 22.1±0.2, 22.7±0.2, 24.9±0.2;
- a crystalline form having peaks at diffraction angle (2θ) of 9.4±0.2, 10.1±0.2, 14.8±0.2, 18.0±0.2, 23.0±0.2, 25.4±0.2, 29.2±0.2;
- a crystalline form having peaks at diffraction angle (2θ) of 5.3±0.2, 10.6±0.2, 17.2±0.2, 19.8±0.2, 26.5±0.2;
- a crystalline form having peaks at diffraction angle (2θ) of 5.1±0.2, 10.2±0.2, 15.2±0.2, 18.6±0.2, 20.5±0.2, 21.9±0.2;
- and
- a crystalline form having peaks at diffraction angle (2θ) of 6.6±0.2, 13.9±0.2, 15.9±0.2, 22.0±0.2, 23.8±0.2, 24.6±0.2, 26.8±0.2.
6 more elements
Dependencies are inferred from the claim text.