The compound of formula I, or an optical isomer thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof, or a prodrug thereof, or a tautomer thereof, or a mesomer thereof, or a racemate thereof, or an enantiomer thereof, or a diastereoisomer thereof, or a mixture thereof, or a metabolite thereof, or a metabolic precursor thereof, or an isotope-substituted form thereof:
- wherein,
- each of rings A, B, and C is independently selected from the group consisting of none, substituted or unsubstituted unsaturated heterocycles, substituted or unsubstituted unsaturated carbocyclic rings, substituted or unsubstituted fused rings;
- preferably, none, substituted or unsubstituted monocyclic aromatic ring, substituted or unsubstituted monocyclic heteroaromatic ring, substituted or unsubstituted fused ring;
- more preferably, none, substituted or unsubstituted 3-8 membered monocyclic aromatic ring, substituted or unsubstituted 3-8-membered monocyclic heteroaromatic ring, substituted or unsubstituted heteroaromatic ring-fused heteroaromatic ring, substituted or unsubstituted benzo-aromatic ring, substituted or unsubstituted benzo-heteroaromatic ring, substituted or unsubstituted benzo-saturated carbocyclic ring, substituted or unsubstituted benzo-saturated heterocyclic ring;
- rings A, B, and C are not none at the same time;
- Each of the substituents on rings A, B, and C is independently selected from the group consisting of deuterium, halogen, —CN, hydroxyl, nitro, amino,
- -L0-OH, -L3-C(O)R7, -L4-CO(O)R8, -L5-(O)COR9, -L6-NHC(O)R10, -L7-C(O)NHR11, -L8-CN, an alkenyl substituted with one or more R12, an alkynyl substituted with one or more R13, an alkyl substituted with one or more R1, an alkoxy substituted with one or more R2, an aryl or an heteroaryl substituted with one or more R3, a cycloalkyl substituted with one or more R5, a heterocyclic group substituted with one or more R6;
- each of said RX, R1, R2, R3, R5, R6, R7, R8, R9, R10, R11, R12, R13 is independently selected from the group consisting of H, deuterium, halogen, —CN, hydroxyl, nitro, amino, alkyl or a deuterated or halogenated compound thereof, -L0-OH, where each of L0, L3, L4, L5, L6, L7, L8 is independently selected from the group consisting of none, C1-C8 alkyl, cycloalkyl;
- R4 is independently selected from the group consisting of H, deuterium, halogen, —CN, hydroxyl, nitro, amino,
- -L0-OH, -L3-C(O)R7, -L4-CO(O)R8, -L5-(O)COR9, -L6-NHC(O)R10, -L7-C(O)NHR11, an alkenyl substituted with one or more R12, an alkynyl substituted with one or more R13, an alkyl substituted with one or more R1, an alkoxy substituted with one or more R2, an aryl or an heteroaryl substituted with one or more R3, a cycloalkyl substituted with one or more R5, a heterocyclic group substituted with one or more R6;
- each of said RX, R1, R2, R3, R5, R6, R7, R8, R9, R10, R11, R12, R13 is independently selected from the group consisting of H, deuterium, halogen, —CN, hydroxyl, nitro, amino, alkyl or a deuterated or halogenated compound thereof, -L0-OH, where each of L0, L3, L4, L5, L6, L7 is independently selected from 0-8 0-8 methylene groups;
- Or, any two groups of the substituents on rings A, B, and C, and R4, together with the substituted atom to which they are linked are connected to form a ring.