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US 2022/0177448 A1Published application
2, 4-diaminopyrimidine derivative and application thereof
AssigneeShanghai Zheye Biotechnology Co. Ltd.
InventorLei Zhang
Life of this patent
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Abstract
The present invention relates to a 2,4-diaminopyrimidine derivative, pharmaceutically acceptable salts thereof, hydrates, solvates or stereoisomers, and a preparation method thereof and an application of the compound used separately or in combination with other drugs in treating diseases having ALK2 kinase-mediated pathological features
Claims16
A compound represented by formula (I),
- or pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof, wherein,
- X, Y and Z are each independently selected from the group consisting of —O—, —NR7—, —S—, —CO—, —SO2—, —SO—, and —(CR7R8)p—;
- R1 is selected from the group consisting of —H, halogen, —OH, —CN, —CF3, —CHF2, —CH2F, —OCF3, —(CH2)qNR9R10—, —CONR9R10, —NO2, —C1-6 alkyl, —C2-6 alkenyl, —C2-6 alkynyl, heteroalkyl, 3-8 membered cycloalkyl, saturated or unsaturated heterocyclyl, aryl and heteroaryl, wherein the alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl can be optionally substituted;
- R2 is selected from the group consisting of —H, halogen, —OH, —CN, —CF3, —CHF2, —CH2F, —OCF3, —(CH2)qNR9R10—, —CONR9R10, —NO2, —C1-6 alkyl, —C2-6 alkenyl, —C2-6 alkynyl, heteroalkyl, —OR9, —COR9, —COOR9 and —NR9COR10, wherein the alkyl, alkenyl, alkynyl or heteroalkyl can be optionally substituted;
- R3 and R4 are each independently selected from the group consisting of —H, halogen, —OH, —CN, —CF3, —CHF2, —CH2F, —OCF3, —(CH2)qNR9R10—, —CONR9R10, —NO2, —C1-6 alkyl, —C2-6 alkenyl, —C2-6 alkynyl, heteroalkyl, —OR9, —COR9, —COOR9, —SO2R9, —NR9COR10, —NR9CONR10R11, —NR9CO2R10, —NR9SO2NR10R11 and —NR9SO2R10, wherein the alkyl, alkenyl, alkynyl or heteroalkyl can be optionally substituted;
- R5 is selected from the group consisting of —H, halogen, —OH, —CN, —CF3, —NO2, —C1-6 alkyl, —C2-6 alkenyl, —C2-6 alkynyl and heteroalkyl, wherein the alkyl, alkenyl, alkynyl or heteroalkyl can be optionally substituted;
- R6 is selected from the group consisting of —H, halogen, —OH, —CN, —CF3, —C1-6 alkyl, —C2-6 alkenyl, —C2-6 alkynyl, heteroalkyl and —OR9;
- R7 and R8 are each independently selected from the group consisting of —H, halogen, —C1-6 alkyl, heteroalkyl, —C2-6 alkenyl, —C2-6 alkynyl, saturated or unsaturated heterocyclyl, oxo, 3-8 membered cycloalkyl, —COR9, —COOR9 and —CONR9R10;
- wherein the alkyl, alkenyl, alkynyl, heterocyclyl or cycloalkyl can be optionally substituted;
- R9, R10 and R11 are each independently selected from the group consisting of —H, heteroalkyl, —C1-6 alkyl, —C2-6 alkenyl, —C2-6 alkynyl, 3-8 membered cycloalkyl, saturated or unsaturated heterocyclyl, aryl and heteroaryl;
- wherein (R9 and R10) and/or (R10 and R11) together with the nitrogen atom to which they are connected form a saturated or unsaturated heterocyclic ring which can be substituted with at least one R12;
- each R12 is independently selected from the group consisting of —H, halogen, —C1-6 alkyl and oxo;
- m is 0, 1, 2 or 3;
- p is 1, 2 or 3;
- q is 0, 1, 2 or 3.
12 more elements
Dependencies are inferred from the claim text.