Alkyne compounds as irak inhibitors, preparation methods and medicinal uses thereof

A compound of formula (I), or a tautomer, mesomer, racemate, enantiomer, diastereomer, or mixture thereof, or a pharmaceutically acceptable salt thereof:

• wherein:
• G is N or CRg;
• R1 is selected from C4-6 alkyl, alkyl substituted by R, —CONRmRn, —COORp, aryl and heteroaryl, wherein the aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyl, hydroxyalkyl, cyano, amino, nitro, —(CH2)r—NRaRb, —C(═O)Rc, —OC(═O)Rc, —OC(═O)ORa, —C(═O)NRaRb, —NRdC(═O)Rc, —NRdC(═O)ORa, —SO2Ra, —SO2NRaRb, —NRdSO2Ra, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• R is selected from halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyl, hydroxyalkyl, cyano, amino, nitro, —(CH2)r—NRaRb, —C(═O)Rc, —C(═O)ORa, —OC(═O)Rc, —C(═O)NRaRb, —NRdC(═O)Rc, —NRdC(═O)ORa, —SO2Ra, —SO2NRaRb, —NRdSO2Ra, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• R2, R5, R9 and Rg are identical or different and are independently selected from hydrogen, halogen, alkyl, haloalkyl, alkoxy, alkylthio, haloalkoxy, haloalkylthio, hydroxyl, hydroxyalkyl, cyano, amino, —(CH2)r—NRaRb, nitro, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• wherein the alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyl, hydroxyalkyl, cyano, amino, nitro, —(CH2)s—NReRf, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• R3 and R4 are identical or different and are independently selected from hydrogen, halogen, alkyl, haloalkyl, alkoxy, alkylthio, haloalkoxy, haloalkylthio, hydroxyl, hydroxyalkyl, cyano, amino and —(CH2)r—NRaRb;
• R6 is selected from alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one or more groups independently selected from halogen, alkyl, haloalkyl, alkoxy, alkylthio, haloalkoxy, hydroxyl, hydroxyalkyl, cyano, amino, nitro, —(CH2)s—NReRf and cycloalkyl;
• R10 at each occurrence is independently selected from hydrogen, halogen, alkyl, haloalkyl, alkoxy, alkylthio, haloalkoxy, haloalkylthio, hydroxyl, hydroxyalkyl, cyano, amino, —(CH2)r—NRaRb, nitro, oxo, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one or more groups independently selected from halogen, alkyl, haloalkyl, alkoxy, alkylthio, haloalkoxy, haloalkylthio, hydroxyl, hydroxyalkyl, cyano, amino, nitro, —(CH2)s—NReRf and cycloalkyl;
• or two R10 together with the attached atoms form a cycloalkyl or heterocyclyl;
• wherein the cycloalkyl and heterocyclyl are optionally substituted with one or more groups independently selected from halogen, alkyl, haloalkyl, alkoxy, alkylthio, haloalkoxy, haloalkylthio, hydroxyl, hydroxyalkyl, cyano, amino, nitro and —(CH2)s—NReRf;
• R7, R8, Ra, Rb, Rc, Rf, Rp, Rm and Rn are identical or different and at each occurrence are independently selected from hydrogen, alkyl, haloalkyl, hydroxyalkyl, —C(═O)ORq, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• or R7 and R8, Ra and Rb, Re and Rf, Rm and Rn together with the nitrogen to which they are attached form a heterocyclyl;
• wherein the heterocyclyl is optionally substituted with one or more groups independently selected from halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyl, hydroxyalkyl, oxo, cyano, amino, nitro, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• Rc at each occurrence is independently selected from alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyl, hydroxyalkyl, cyano, amino and nitro;
• Rd at each occurrence are independently selected from hydrogen, alkyl, haloalkyl, hydroxyalkyl and cycloalkyl, wherein the cycloalkyl is optionally substituted with one or more groups independently selected from halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyl, hydroxyalkyl, cyano, amino, and nitro;
• Rq is selected from hydrogen, alkyl and haloalkyl;
• n is 0, 1, 2, 3 or 4;
• r is 0, 1, 2 or 3;
• and
• s is 0, 1, 2 or 3.