Nuclear transport modulators and uses thereof
AssigneeKaryopharm Therapeutics Inc.
InventorsErkan Baloglu, Sharon Shacham, Dilara McCauley, Trinayan Kashyap, William Senapedis, Yosef Landesman, Gali Golan, Ori Kalid, Sharon Shechter
Life of this patent
Estimating the term…
Abstract
The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I or their pharmaceutically acceptable salts, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.
Claims46
(canceled)
A compound, represented by structural formula IV:
- or a pharmaceutically acceptable salt thereof, wherein:
- R2 is selected from optionally substituted heteroaryl and optionally substituted aryl.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
A compound of structural formula III:
- or a pharmaceutically acceptable salt thereof, wherein:
- Rb is selected from —C(O)OH, —C(O)NH2, —C(O)—N(R7)—N(R5)(R6), —C(O)—N(R7)—N(R7)—C(O)—R4 and —C(O)—N(R7)—N(R7)—S(O)1-2—R4;
- wherein:
- R4 is selected from —N(H)(C3-C6 cycloalkyl), —N(C1-C4 alkyl)(C3-C6 cycloalkyl), —C1-C6 alkyl, —(C0-C4 alkylene)-carbocyclyl, —(C0-C4 alkylene)-heterocyclyl, —(C0-C4 alkylene)-aryl, and —(C0-C4 alkylene)-heteroaryl;
- R5 and R6 are each independently selected from hydrogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, carbocyclyl, aryl, heterocyclyl and heteroaryl;
- or
- R5 and R6 are taken together with the nitrogen atom to which they are commonly attached to form a heterocyclyl or heteroaryl;
- and
- each R7 is independently hydrogen or C1-C4 alkyl;
- and
- R2 is an optionally substituted C5-C15 heteroaryl, wherein:
- unless otherwise designated, each alkyl, alkenyl, alkynyl, alkylene, carbocyclyl, aryl, cycloalkyl, heterocyclyl and heteroaryl is optionally and independently substituted.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
A compound represented by any one of the following structural formulas:
- or a pharmaceutically acceptable salt of any of the foregoing.
(canceled)
(canceled)
Dependencies are inferred from the claim text.