Inert nanocapsules
AssigneeThe University Court of the University of Edinburgh
InventorsPaul LUSBY, Michael BURKE, William GRANTHAM, Steve ARCHIBALD, Benjamin BURKE
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Abstract
Compounds are presented having the formula [M4L6].Xn, where M is a transition metal ion having 6 d-shell valence electrons, X is a counter ion and n is the number of counterions such that the total charge of the compound of formula (I) is zero, and wherein L is a 5-(5-bipyridin-2,2′-yl)-2,2′-bipyridine or derivative thereof. Methods of preparing the compounds and uses of the compounds to retain radiolabels are also presented.
Claims20
A compound of formula I
- [M4L6].Xn, (I)
- wherein M is a transition metal ion having 6 d-shell valence electrons;
- wherein X is a counter ion and n is the number of counterions such that the total charge of the compound of formula I is zero;
- and
- wherein L has formula II
- wherein R1, R2, R3, R6, R7, R8, R9, R10, R13 and R14 are independently H, OR15, OCOR15, OC(O)OR15, OP(O)(OR15)(OR16), OP(O)R15R16, SR15, SCOR15, SC(O)OR15, SP(O)(OR15)(OR16), SP(O)R15R16, NR15R16, NR16COR15, NR16CO2R15 or NR17P(O)(OR15)(OR16);
- wherein R4 and R5 are H or linked CH groups to form an N,N-phenanthroline ring, and/or R11 and R12 are H or linked CH groups to form an N,N-phenanthroline ring;
- wherein R15, R16 and R17 are independently selected from H and C1-C10 alkyl, polyethylene glycol (PEG) and polyether groups;
- and
- wherein Z is selected from a chemical bond, acetylene, disubstituted phenylene, naphthalene, anthracene, pyrene or similar chemically rigid spacer.
A method of preparing a compound according to formula I, the method comprising the steps:
- a. providing a first solution comprising transition metal ions M having 7 d-shell valence electrons, and a second solution comprising ligands according to formula II;
- b. mixing the first solution with the second solution;
- c. oxidising the transition metal ions M in the resulting compound, such that the structure of the complex becomes fixed.
A method of preparing a compound according to formula VI,
- [M4L6].Xn.T (VI)
- the method comprising the steps:
- a. providing a compound according to formula I;
- b. providing a target species T;
- c. combining the compound according to formula I with the target species to form the compound according to formula VI.
A method of using the compound according to formula VI for diagnosis comprising the steps;
- providing a compound according to formula VI;
- administering the compound to a subject;
- and
- monitoring the location and/or movement of the compound within the subject.
Dependencies are inferred from the claim text.