Pharmaceutical Packaging System and Method of Manufacturing Same

A method of manufacturing a pharmaceutical packaging system containing at least one orally-administered medicament and a first topically-applied medicament, the method comprising:

• providing, into a first filling cabinet, a substrate having a first surface, a first hollow cavity accessible through a first opening in the first surface, and a second hollow cavity accessible through a second opening in the first surface, the first and second hollow cavities being spaced apart and isolated from one another on the substrate;
• feeding, while the substrate is in the first filling cabinet, the at least one orally-administered medicament or the first topically-applied medicament into the first hollow cavity;
• providing a cover for the first surface of the substrate and sealing the cover to the first surface of the substrate at a portion surrounding the first hollow cavity to provide a first seal;
• providing the substrate into a second filling cabinet having a different internal pressure than the first filling cabinet;
• partially moving the cover away from the first surface of the substrate to expose the second hollow cavity;
• feeding, while the substrate is in the second filling cabinet, the other of the at least one orally-administered medicament or the first topically-applied medicament into the second hollow cavity;
• and
• sealing the cover to the first surface of the substrate at a portion surrounding the second hollow cavity to provide a second seal.