Geometry-based real-time adaptive radiotherapy

A non-transitory computer-readable medium comprising non-transitory computer-readable instructions for adjusting radiotherapy treatment for a patient in real time, the computer-readable instructions comprising instructions for performing operations comprising:

• retrieving a reference plan that includes three-dimensional (3D) volume representation of information for the patient and a plurality of radiotherapy beam delivery segments;
• identifying a first portion of the 3D volume representation of information for a first beam delivery segment of the plurality of radiotherapy beam delivery segments that includes a volumetric portion of a target irradiated by the first beam delivery segment;
• accessing a deformation model representing patient deformation during a radiotherapy treatment fraction;
• deforming the first portion of the 3D volume representation of information based on the deformation model;
• and
• updating one or more parameters of a radiotherapy treatment device based on the deformed first portion of the 3D volume representation of information.

A system for adjusting radiotherapy treatment for a patient in real time, the system comprising:

• one or more processors for performing operations comprising:
• retrieving a reference plan that includes three-dimensional (3D) volume representation of information for the patient and a plurality of radiotherapy beam delivery segments;
• identifying a first portion of the 3D volume representation of information for a first beam delivery segment of the plurality of radiotherapy beam delivery segments that includes a volumetric portion of a target irradiated by the first beam delivery segment;
• accessing a deformation model representing patient deformation during a radiotherapy treatment fraction;
• deforming the first portion of the 3D volume representation of information based on the deformation model;
• and
• updating one or more parameters of a radiotherapy treatment device based on the deformed first portion of the 3D volume representation of information.