Microneedles to deliver therapeutic agent across membranes
OwnerAykut AKSIT, Anil K. LALWANI +2inventors
InventorsAykut AKSIT, Anil K. LALWANI, Jeffrey W. KYSAR, Alan WEST
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Abstract
The disclosed subject matter relates to a system and method for delivery of therapeutic agents across membranes such as to the inner ear. The system includes a plurality of microneedles that can be delivered to the round window membrane by a delivery device, e.g. catheter, and is capable of controlled penetration of the round window membrane to create temporary and self-closing perforations.
Claims43
A microneedle for perforation of an anatomic membrane, the metal microneedle having a fully metal body, the body comprising a proximal portion, a distal portion and a length there between, the proximal portion including a longitudinal shaft having an outer diameter of about 100 micron and a microneedle height of about 450 micron, wherein microneedle is configured to create a perforation of an anatomic membrane that self-closes within a period of time, wherein the period of time is one week or less.
A pyrolyzed microneedle comprising
- a pyrolyzed body having a tip, base, and length therebetween, wherein the body comprises an atomic percentage of carbon of greater than 85%.
A pyrolyzed microneedle comprising
- a pyrolyzed body having a tip, base, and length therebetween, wherein the body comprises an atomic percentage of about 94% and an atomic percentage of oxygen of less than 5% percent.
A pyrolyzed microneedle comprising
- a pyrolyzed body having a tip, base, and length therebetween, wherein the pyrolyzed body comprises an atomic percentage of carbon of greater than 85%, and the outer diameter of the pyrolized microneedle is about 20 micron and the length is less than 200 micron.
Dependencies are inferred from the claim text.