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US 2022/0176084 A1Published application
Medical device with drug-eluting coating on modified device surface
AssigneeBard Peripheral Vascular, Inc.
InventorJacob Mertens
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AssigneeBard Peripheral Vascular, Inc.
InventorJacob Mertens
Estimating the term…
Medical devices such as stents, stent grafts, and balloon catheters include a coating layer applied over a modified exterior surface of the medical device. The modified exterior surface comprises an exterior surface of the medical device subjected to a surface modification that decreases a surface free energy of the exterior surface before application of the coating layer an exterior surface. The coating layer comprises a hydrophobic therapeutic agent and at least one additive. The modified exterior surface may affect the release kinetics of the drug from the device, the crystallinity of the drug layer, the surface morphology of the coating and particle shape, or the particle size of drug of a therapeutic layer in the coating layer. For example, the effects caused by the modified exterior surface may increase the retention time and amount of therapeutic agent in tissue.
A medical device comprising a micropatterned surface and a coating layer overlying the micropatterned surface, wherein:
A method for preparing a medical device that provides increased tissue retention of a therapeutic agent at a target site of a diseased lumen in vasculature of a patient in need of the therapeutic agent, the method comprising:
The method of claim 13, wherein micropatterning comprises forming a plurality of recesses and protrusions on the exterior surface of the device.
The method of claim 13, wherein micropatterning comprises forming a plurality of recesses and protrusions on the intermediate layer.
A method of providing a therapeutic treatment in a subject, the method comprising:
Dependencies are inferred from the claim text.